Lorenzo's Oil is a 1992 drama film directed by George Miller, based on the true story of Augusto and Michaela Odone's quest to find a cure for their son Lorenzo's adrenoleukodystrophy (ALD). The film stars Nick Nolte and Susan Sarandon, who received an Academy Award nomination for Best Actress for her role. Despite its critical acclaim, the film was a box office disappointment, grossing $7.2 million against its $30 million budget. ([en.wikipedia.org](https://en.wikipedia.org/wiki/Lorenzo%27s_Oil?utm_source=openai))